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Updated: Jun 26, 2026
Evaluating the Anti-depression Effect of Xiaoyaosan on Chronically-stressed Mice
Published on: January 7, 2019
[Effects of Xiaoyao Wan on the behavioral despair and stress depression mice]
1School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China. libao0133@163.com
Objective:
To investigate the anti-depressant effect and the possible mechanism of Xiaoyao Wan in animal models.
Methods:
The open-field test and the forced swimming test were applied to study the anti-depressant effect of Xiaoyao Wan in mice, and HPLC-ECD was carried out to assay the contents of 5-HT and 5-HIAA, and the mechanism of Xiaoyao Wan on anti-depressant effect was discussed.
Results:
Xiaoyao Wan at the dose of 200, 400 and 600 mg/kg significantly increased the revolutions in force swimming test, and ameliorated brain cortex 5-HT and 5-HIAA content of restraint mice. But there was no effect on brain cortex 5-HT and 5-HIAA content of non-restraint mice.
Conclusion:
Xiaoyao Wan has significant anti-depressant effect which may be related to the potentiation of brain serotonergic function.
