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Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds the telomeric...
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Updated: Jun 26, 2026

Techniques to Induce and Quantify Cellular Senescence
06:51

Techniques to Induce and Quantify Cellular Senescence

Published on: May 1, 2017

Cellular senescence: hot or what?

Gerard I Evan1, Fabrizio d'Adda di Fagagna

  • 1Department of Pathology and Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA 94143-0502, USA.

Current Opinion in Genetics & Development
|February 3, 2009
PubMed
Summary
This summary is machine-generated.

Cellular senescence, a state where cells stop dividing, acts as a tumor suppressor. However, it can be bypassed during cancer progression and is linked to fibrosis and inflammation.

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Induction and Validation of Cellular Senescence in Primary Human Cells
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A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence
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A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence

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Last Updated: Jun 26, 2026

Techniques to Induce and Quantify Cellular Senescence
06:51

Techniques to Induce and Quantify Cellular Senescence

Published on: May 1, 2017

Induction and Validation of Cellular Senescence in Primary Human Cells
08:18

Induction and Validation of Cellular Senescence in Primary Human Cells

Published on: June 20, 2018

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence
13:59

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence

Published on: August 12, 2018

Area of Science:

  • Cellular Biology
  • Oncology
  • Molecular Biology

Background:

  • Cellular senescence, the irreversible cessation of cell division, was first described over 40 years ago.
  • Recent findings indicate that cellular senescence functions as a tumor-preventive mechanism, akin to oncogene-induced apoptosis.
  • The interplay between the DNA damage response and the ARF tumor suppressor in oncogene-induced senescence is a key area of investigation.

Purpose of the Study:

  • To explore the multifaceted roles of cellular senescence in cancer prevention and progression.
  • To investigate the mechanisms underlying oncogene-induced senescence, focusing on the DNA damage response and ARF pathway.
  • To examine the implications of cellular senescence in epithelial-mesenchymal transition, organ fibrosis, and inflammation.

Main Methods:

  • Review of existing literature on cellular senescence.
  • Analysis of studies investigating oncogene-induced senescence pathways.
  • Examination of research on the role of senescence in epithelial-mesenchymal transition, fibrosis, and inflammation.

Main Results:

  • Cellular senescence is triggered by activated oncogenes, acting as a critical tumor suppressor.
  • Both DNA damage response and ARF tumor suppressor pathways are implicated in oncogene-induced senescence.
  • Cellular senescence can be bypassed during epithelial-mesenchymal transition, and it is implicated in organ fibrosis and inflammation.

Conclusions:

  • Cellular senescence is a fundamental biological process with critical roles in tumor suppression.
  • Further research is needed to fully elucidate the interactions between DNA damage response and ARF in senescence.
  • The involvement of cellular senescence in processes like EMT, fibrosis, and inflammation highlights its significance in various pathological conditions.