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Determination of sultopride and tiapride in serum by gas chromatography using a surface ionisation detector
A Kamizono1, N Inotsume, K Miyamoto
1Department of Pharmaceutical Services, Kumamoto University Hospital, Japan.
Journal of Chromatography
|June 14, 1991
Abstract:
A sensitive and selective method has been developed for the determination of sultopride and tiapride in serum using gas chromatography with a surface ionisation detector. No interfering peaks from endogenous substances were observed. The method showed good reproducibility and accuracy, and the standard curve was linear up to 2 micrograms/ml with a correlation coefficient of 0.999. This method is applicable to pharmacokinetic studies and therapeutic drug monitoring of sultopride and tiapride.