[Modulating effect of serotonin on the development of human leukocytes apoptosis induced by Yersinia]

Effect of biogenic amine serotonin on the development of human blood leukocytes during interaction with species from Yersinia genus (Y. pestis EV, Y. pseudotuberculosis serovars I and IV, Y. enterocolitica serovars 09 and 03) was studied in model system in vitro using flow cytofluorometry. Serotonin in concentration 10(-5) M had differently marked effects on Yersinia spp.-induced apoptosis of leukocytes. Pattern of the observed changes depended from species and serovar of Yersinia. Serotonin inhibited development of early (after 6 hours) apoptosis of leukocytes induced by Y. pestis and Y. pseudotuberculosis serovar I.