Related Experiment Video
Updated: Jun 25, 2026

Alternative Methods for the Detection of Superoxide Anion Generation in Platelets
Published on: March 29, 2024
The plasma membrane redox system in human platelet functions and platelet-leukocyte interactions
Domenico Del Principe1, Gianluca Frega, Isabella Savini
1Department of Health and Cell Biology, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy. delprin@uniroma2.it
Abstract:
The plasma membrane electron transport is crucial for blood coagulation and thrombosis, since reactive oxygen species and thiol changes, generated by plasma membrane redox reactions, modulate activation of platelets, as well as their interaction with leukocytes. Several antioxidants are linked to this system; thus, platelets are also able to counterbalance radical production and to regulate thrombus growth. Aim of this review is to give an update on the plasma membrane redox system in platelets, as well as on its role in platelet functions and leukocyte-platelet cross-talk.
More Related Videos
Related Concept Videos
Structure and Function of Platelets
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000 platelets, with...
Formation of the Platelet Plug
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
What are Membranes?
Redox Reactions
Structure and Function of Leukocytes
White blood cells protect the body...
Inflammation

