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Updated: Jun 25, 2026
04:42
Developing a Rat Model for Bipolar Disorder
Published on: May 2, 2025
Treating mania in Wilson's disease with lithium
Santosh Loganathan1, Raghavendra Nayak, Sanjib Sinha
1Department of Psychiatry, National Institute of Mental Health and Neurosciences (NIMHANS), Hosur Rd., Bangalore, Karnataka, 560038, India. santoshl_28@yahoo.co.in
The Journal of Neuropsychiatry and Clinical Neurosciences
|February 7, 2009
Summary
No abstract available in PubMed .
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01:14Acid Halides to Ketones: Gilman Reagent
Lithium dialkyl cuprate, also known as Gilman reagents, selectively reduces acid halides to ketones. The acid chloride is treated with Gilman reagent at −78 °C in the presence of ether solution to produce a ketone in good yield.
As shown below, the mechanism proceeds in two steps. First, one of the alkyl groups of the reagent acts as a nucleophile and attacks the acyl carbon of the acid chloride to form a tetrahedral intermediate. This is followed by the reformation of the carbon–oxygen double...
As shown below, the mechanism proceeds in two steps. First, one of the alkyl groups of the reagent acts as a nucleophile and attacks the acyl carbon of the acid chloride to form a tetrahedral intermediate. This is followed by the reformation of the carbon–oxygen double...