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Updated: Jun 25, 2026

Combining QD-FRET and Microfluidics to Monitor DNA Nanocomplex Self-Assembly in Real-Time
Published on: August 26, 2009
DNA-directed self-assembly of fluorescent dye-labeled streptavidin arrays for protein detection
Junping Zhang1, Roger J Narayan
1Department of Biomedical Engineering, University of North Carolina, Chapel Hill, NC 27599, USA.
Abstract:
In this work, a DNA lattice was utilized to direct protein self-assembly. A model biosensor system was fabricated by self-assembly of rhodamine dye-labeled streptavidin molecules on a two-tile DNA system. This self-assembly nanofabrication technique has numerous possible biotechnology applications, including use in multiplex biosensing systems that have binding of several biological molecules encoded in a multiple-tile DNA lattice.
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