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Multimodal Analytical Platform on a Multiplexed Surface Plasmon Resonance Imaging Chip for the Analysis of Extracellular Vesicle Subsets
Published on: March 17, 2023
On-chip surface plasmon resonance sensor
Hyungseok Pang1, Hyoung J Cho, Patrick L Likamwa
1College of Optics and Photonics: CREOL and FPCE, University of Central Florida, Orlando, Florida, 32816, USA.
Journal of Nanoscience and Nanotechnology
|February 10, 2009
Summary
A new on-chip micro surface plasmon resonance (SPR) sensor was developed on an optoelectronic platform. This miniaturized, high-throughput sensor shows potential for advanced biosensing applications.
Area of Science:
- Optoelectronics
- Nanotechnology
- Biosensing
Background:
- Surface Plasmon Resonance (SPR) is a powerful label-free optical sensing technique.
- Current SPR systems can be bulky and lack integration, limiting high-throughput applications.
- Developing miniaturized and integrated SPR sensors is crucial for point-of-care diagnostics and advanced research.
Purpose of the Study:
- To develop a novel on-chip micro SPR sensor.
- To create a fully integrated SPR sensor system for miniaturization and high throughput.
- To investigate a new method for the design and fabrication of solid-state SPR sensor devices.
Main Methods:
- Development of an optoelectronic platform for the SPR sensor.
- Design and fabrication of a novel solid-state SPR sensor device.
- Proof-of-concept demonstration using a simulated binding experiment to generate and detect SPR signals.
Main Results:
- Successful development of a novel on-chip micro SPR sensor.
- Demonstration of signal generation and detection from the proposed optoelectronic platform.
- Validation of the fabricated solid-state SPR sensor device through simulated binding.
Conclusions:
- The developed on-chip micro SPR sensor represents a significant advancement in integrated sensing technology.
- The optoelectronic platform enables a miniaturized and high-throughput SPR sensing system.
- This novel sensor design and fabrication method pave the way for future high-performance biosensing applications.
