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Optimal extravascular dosing intervals.

P Veng-Pedersen¹, N B Modi

¹College of Pharmacy, University of Iowa, Iowa City 52242.

Journal of Pharmacokinetics and Biopharmaceutics

|August 1, 1991

Summary

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A new formula simplifies calculating drug dosing time (tau) for a steady-state peak-to-trough ratio of 2. This method ensures less than 1% error, offering a reliable approach for optimizing drug intervals.

Area of Science:

Pharmacokinetics and Pharmacodynamics
Computational Pharmacology
Drug Dosing Optimization

Background:

Achieving a target steady-state peak-to-trough ratio is crucial for effective drug therapy.
Accurate calculation of dosing intervals (tau) is essential for maintaining therapeutic drug concentrations.
Existing methods for calculating tau may have limitations in error bounds and applicability.

Purpose of the Study:

To present an explicit and simple formula for calculating the dosing time (tau) for a steady-state peak-to-trough ratio of 2 in extravascular dosings.
To ensure the proposed formula has guaranteed error bounds (less than 1%) for all parameter combinations.
To demonstrate the formula's utility in determining optimal dosing intervals for specific drugs.

Main Methods:

Related Experiment Videos

Development of an explicit formula for calculating dosing time (tau).
Transformation of the biexponential dosing interval problem into a general, dimensionless problem for global error analysis.
Application of the formula to calculate the optimal dosing interval for quinidine.

Main Results:

An explicit formula for calculating dosing time (tau) yielding a steady-state peak-to-trough ratio of 2 is presented.
The formula guarantees a maximum percentage error of less than 1% across all parameter value combinations.
The proposed method was successfully applied to determine an optimal dosing interval for quinidine.

Conclusions:

The presented explicit formula offers a simple, accurate, and reliable method for calculating dosing time (tau) to achieve a specific steady-state peak-to-trough ratio.
The guaranteed error bound of less than 1% provides a significant advantage over existing formulae.
The developed algorithm and computer program (OPTAU) facilitate exact calculations and simulations for drug dosing optimization.