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Updated: Jun 25, 2026

Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS
Published on: November 8, 2015
[Changes of immunologically-mediated resistance factors after low-intensity longitudinal immunosuppressive effect]
Abstract:
The aim of the article was to determine the effect of intra peritoneal injections of cyclophosphamide on non-specific immunologically mediated resistance. The experiment was conducted on mice. Alternate-day cyclophosphamide was administrated in three dosage schedules: "high" (200 mg/kg), "middle" (20 mg/kg) and "low" (2 mg/kg) for 20 days. The investigation showed that administration of "high" dose cyclophosphamide caused the development of severe depression of non-specific immunologically mediated resistance. Administration of "low" dose cyclophosphamide did not promote non-specific immunologically mediated resistance depression. Moreover administration of "low" dose of CP expressed ability to moderately stimulate non-specific immunologically mediated resistance. However further investigation is needed to study depressive effect of "low" dose cyclophosphamide.
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