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iChip

iChip

The cultivation of environmental microorganisms has long been hindered by the inability to replicate complex native conditions in vitro. The isolation chip (iChip) addresses this limitation by facilitating the growth of previously uncultivable microorganisms through in situ incubation. Designed for high-throughput microbial cultivation, the iChip comprises hundreds of microchambers, each capable of housing a single microbial cell. These microchambers are loaded with a mixture of molten agar and...

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Updated: Jun 25, 2026

A Microfluidic-based Electrochemical Biochip for Label-free DNA Hybridization Analysis

A Microfluidic-based Electrochemical Biochip for Label-free DNA Hybridization Analysis

Published on: September 10, 2014

Bio-cell chip fabrication and applications.

Honggu Chun¹, Dong Soon Lee, Hee Chan Kim

¹Department of Biomedical Engineering, College of Medicine, Seoul National University, Seoul, Korea.

Methods in Molecular Biology (Clifton, N.J.)

|February 13, 2009

Summary

Researchers developed a novel bio-cell chip for studying cell interactions. This microarray technology enables detailed gene and protein interaction analysis with preserved cellular structure, offering a cost-effective diagnostic tool.

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Last Updated: Jun 25, 2026

A Microfluidic-based Electrochemical Biochip for Label-free DNA Hybridization Analysis

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Published on: March 2, 2020

Area of Science:

Biotechnology
Cell Biology
Microfluidics

Background:

Bio-cell chips are microarrays designed to hold intact cells for studying cellular interactions.
They offer three-dimensional positional information crucial for understanding gene-gene and gene-protein interactions.

Purpose of the Study:

To develop and characterize a novel bio-cell chip for cell-based assays.
To evaluate its potential for basic research and clinical diagnostics.

Main Methods:

Fabrication of a 16 x 6 array bio-cell chip using a perforated polydimethylsiloxane (PDMS) layer on a glass slide.
Seeding of mononuclear cells from bone marrow specimens into the chip's wells.
Application of fluorescent in situ hybridization (FISH) for cellular analysis.

Main Results:

The bio-cell chip successfully contained intact cells within micro-wells.
FISH analysis was performed on cells cultured on the chip.
The technology demonstrated compatibility with standard clinical protocols.

Conclusions:

Bio-cell chip technology is a cost-effective and rapid method for analyzing cellular interactions.
It requires minimal sample volume, making it suitable for clinical diagnosis.
The platform is valuable for both fundamental research and diagnostic applications.