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Updated: Jun 25, 2026

Quantification of Orofacial Phenotypes in Xenopus
Published on: November 6, 2014
Bivariate or composite plots of endpoints
1Jiann-Ping Hsu College of Public Health, Georgia Southern University, Statesboro, Georgia, USA. kepeace@georgiasouthern.edu
Abstract:
Clinical trials often identify two endpoints or response measures of interest. Depending on the drugs and the disease, the endpoints may be correlated or uncorrelated, reflect efficacy or safety, or one or both may be considered as primary. For visualization, plots of each endpoint from baseline to the end of the trial are presented for each treatment group. This paper illustrates the usefulness of developing bivariate, composite plots of both endpoints jointly. Two applications are presented: one of a fixed combination drug for treating allergic rhinitis, and the other of a dose comparison trial in duodenal ulcer.
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