Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cryptococcal Meningitis01:27

Cryptococcal Meningitis

Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin create...
Amebiasis01:28

Amebiasis

Entamoeba histolytica, a protozoan parasite, is responsible for intestinal and extraintestinal amebiasis. Though a significant proportion of infections remain asymptomatic, approximately 50 million individuals annually are estimated to present with clinical disease, resulting in up to 100,000 deaths globally. The disease burden is disproportionately high in regions with lower socioeconomic status, such as parts of India, Africa, Mexico, and Latin America.Etiology and TransmissionThe infective...
Pneumonia I: Introduction01:29

Pneumonia I: Introduction

Pneumonia is an infection of the lower respiratory tract that leads to inflammation of the lung parenchyma, often resulting in the accumulation of inflammatory exudate in the alveoli and airways. Unlike the watery, low-protein fluid exudate in pulmonary edema, the exudate in this case is a thick fluid rich in immune cells, proteins, and debris produced during infection and inflammation.This impairs gas exchange and can lead to consolidation of lung tissue. The infection may be caused by a...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A national survey of the provision of prehabilitation for oesophagogastric cancer patients in the UK.

Annals of the Royal College of Surgeons of England·2024
Same author

Exercise During Chemotherapy for Cancer: A Systematic Review.

Journal of surgical oncology·2024
Same author

[Epidemiological and clinical profile childhood cancers with pleural and pulmonary lesions in the pediatric oncology unit of Treichville University Hospital (Abidjan, Côte d'Ivoire)].

Revue des maladies respiratoires·2022
Same author

Response to the Letter to the Editor: "Risk of Adverse Reactions to Oral Antibiotics Prescribed by Dentists".

Journal of dental research·2020
Same author

Machine learning to predict early recurrence after oesophageal cancer surgery.

The British journal of surgery·2020
Same author

International Society of Cardiovascular Infectious Diseases Guidelines for the Diagnosis, Treatment and Prevention of Disseminated Mycobacterium chimaera Infection Following Cardiac Surgery with Cardiopulmonary Bypass.

The Journal of hospital infection·2019

Related Experiment Video

Updated: Jun 25, 2026

Passive Administration of Monoclonal Antibodies Against H. capsulatum and Others Fungal Pathogens
09:57

Passive Administration of Monoclonal Antibodies Against H. capsulatum and Others Fungal Pathogens

Published on: February 14, 2011

Risk factor analysis of Histoplasma capsulatum fungemia.

M A Assi1, M S Sandid, L M Baddour

  • 1Division of Infectious Diseases, Mayo Clinic College of Medicine, Rochester, Minnesota, USA. maassi@hotmail.com

Medical Mycology
|February 13, 2009
PubMed
Summary

Immunocompromised status and low peripheral leukocyte count (WBC) are key risk factors for Histoplasma capsulatum fungemia, a serious fungal infection. Identifying these factors aids in early detection and management of this condition.

More Related Videos

Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis
09:52

Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis

Published on: March 9, 2018

Use of Image Cytometry for Quantification of Pathogenic Fungi in Association with Host Cells
07:58

Use of Image Cytometry for Quantification of Pathogenic Fungi in Association with Host Cells

Published on: June 19, 2013

Related Experiment Videos

Last Updated: Jun 25, 2026

Passive Administration of Monoclonal Antibodies Against H. capsulatum and Others Fungal Pathogens
09:57

Passive Administration of Monoclonal Antibodies Against H. capsulatum and Others Fungal Pathogens

Published on: February 14, 2011

Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis
09:52

Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis

Published on: March 9, 2018

Use of Image Cytometry for Quantification of Pathogenic Fungi in Association with Host Cells
07:58

Use of Image Cytometry for Quantification of Pathogenic Fungi in Association with Host Cells

Published on: June 19, 2013

Area of Science:

  • Medical Mycology
  • Infectious Diseases
  • Epidemiology

Background:

  • Histoplasma capsulatum fungemia is a severe manifestation of histoplasmosis.
  • Risk factors for developing H. capsulatum fungemia require further investigation for improved patient outcomes.

Purpose of the Study:

  • To identify independent risk factors associated with Histoplasma capsulatum fungemia.
  • To analyze patient data retrospectively to determine predictors of H. capsulatum fungemia.

Main Methods:

  • A retrospective case-control study was conducted involving 111 patients diagnosed with histoplasmosis.
  • Blood cultures were analyzed to identify cases of H. capsulatum fungemia (55 patients) versus controls (56 patients).
  • Univariate and multivariable analyses were performed to assess risk factors including immunocompromised status, leukocyte count, albumin levels, and Charlson score.

Main Results:

  • Immunocompromised status (Odds Ratio [OR] 2.4, P=0.043) and a peripheral leukocyte count (WBC) below 3000 cells/mm³ (OR 6.5, P=0.001) were significant independent risk factors for H. capsulatum fungemia.
  • Univariate analysis also identified low albumin and high Charlson scores as potential risk factors.
  • Age over 55 years was not found to be a significant risk factor.

Conclusions:

  • Immunocompromised status and a low peripheral leukocyte count (WBC < 3000 cells/mm³) are significant independent risk factors for H. capsulatum fungemia.
  • These findings highlight the importance of monitoring WBC counts in immunocompromised individuals at risk for histoplasmosis.
  • Early recognition of these risk factors can guide clinical management and potentially reduce the incidence of fungemia.