Related Experiment Video
Updated: Jun 25, 2026

Implantation of Osmotic Pumps and Induction of Stress to Establish a Symptomatic, Pharmacological Mouse Model for DYT/PARK-ATP1A3 Dystonia
Published on: September 12, 2020
The pathophysiology of focal hand dystonia
1Human Motor Control Section, NINDS/NIH, Bethesda, Maryland 20892-1428, USA. linpe@ninds.nih.gov
Abstract:
NARRATIVE REVIEW: Focal hand dystonia is a disabling movement disorder, often task specific, that leads to impaired hand use. In addition to a genetic predisposition, environmental risk factors including repetitive use and musculoskeletal constraints are contributory. Although the underlying cause is unknown, recent studies have identified several key mechanisms that may play a part in its genesis. Failure of inhibition, abnormal sensorimotor integration, and maladaptive plasticity seem to be important. Understanding the underlying physiology may lead to the design of novel therapies.
Related Concept Videos
Alterations in Muscle Tone ll
Alterations in Muscle Tone lll
Parkinson's Disease: Overview
Huntington Disease l: Introduction
Parkinson Disease ll: Pathophysiology
Myasthenia Gravis ll: Pathophysiology
