Related Experiment Video
Updated: Jun 25, 2026
05:48
Rapid Generation of Amyloid from Native Proteins In vitro
Published on: December 5, 2013
[Secondary amyloidosis in Crohn's disease]
S Seijo Ríos1, M Barreiro de Acosta, B Vieites Pérez-Quintela
1Servicios de Aparato Digestivo, Hospital Clínico Universitario de Santiago, Santiago de Compostela, A Coruña. susana-seijo@hotmail.com
Revista Espanola De Enfermedades Digestivas
|February 19, 2009
Summary
Secondary amyloidosis, a rare complication, can worsen outcomes for patients with inflammatory bowel disease, particularly Crohn's disease. This report details two cases of Crohn's disease linked to secondary amyloidosis.
Area of Science:
- Medicine
- Pathology
- Gastroenterology
Background:
- Amyloidosis involves extracellular protein deposition, disrupting organ architecture and function.
- Secondary amyloidosis is a serious complication associated with chronic inflammatory diseases, infections, or cancer.
- Inflammatory bowel disease (IBD), especially Crohn's disease, is a known risk factor for secondary amyloidosis.
Observation:
- This report presents two clinical cases.
- Both cases involve patients diagnosed with Crohn's disease.
- Secondary amyloidosis was identified as a complication in these patients.
Findings:
- The study highlights the co-occurrence of Crohn's disease and secondary amyloidosis.
- It underscores the potential for amyloidosis to complicate the clinical course of IBD.
- The findings emphasize the importance of recognizing this association in patient management.
Implications:
- Early detection and management of secondary amyloidosis are crucial for improving Crohn's disease prognosis.
- This association warrants further investigation into the underlying mechanisms.
- Clinicians should consider screening for amyloidosis in Crohn's disease patients presenting with relevant symptoms.
Related Concept Videos
03:03Amyloid Fibrils
Amyloid fibrils are aggregates of misfolded proteins. Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils.
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining, normally used to...
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining, normally used to...
03:03Amyloid Fibrils
Amyloid fibrils are aggregates of misfolded proteins. Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils.
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining, normally used to...
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining, normally used to...
01:25Inflammatory Bowel Disease III: Crohn's Disease
Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
01:30Inflammatory Bowel Disease II: Crohn's Disease
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
01:23Alzheimer Disease ll: Pathophysiology
Alzheimer disease involves structural changes in the brain that begin long before symptoms appear. The most distinctive features are extracellular neuritic plaques and intracellular neurofibrillary tangles.Neuritic plaques form in the cerebral cortex and around blood vessels. These plaques contain a dense core of beta-amyloid (Aβ)—a toxic protein fragment that clumps outside neurons. The core is surrounded by damaged neuronal extensions, as well as reactive astrocytes and microglia. Abnormal...
01:24Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab (Humira),...