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Published on: August 22, 2012
Crimean-Congo haemorrhagic fever among children in north-eastern Turkey
1Department of Pediatrics, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey.
Insights
Crimean-Congo haemorrhagic fever (CCHF) in children presents with fever, nausea, and malaise, often following tick bites. Early diagnosis and specialized care are crucial for better outcomes in CCHF pediatric cases.
Area of Science:
- Epidemiology
- Pediatrics
- Infectious Diseases
Background:
- Crimeyan-Congo haemorrhagic fever (CCHF) is a tick-borne viral disease with significant public health implications.
- Pediatric CCHF cases present unique challenges in diagnosis and management.
- Understanding the epidemiological and clinical spectrum of CCHF in children is vital for effective public health strategies.
Purpose of the Study:
- To analyze the epidemiological and clinical characteristics of pediatric Crimean-Congo haemorrhagic fever (CCHF) cases.
- To identify key symptoms, laboratory findings, and risk factors associated with CCHF in children.
- To evaluate treatment modalities and outcomes in children diagnosed with CCHF.
Main Methods:
- Retrospective study design.
- Analysis of demographic data, clinical presentations, and laboratory findings in 21 pediatric CCHF patients.
- Review of treatment approaches and patient outcomes.
Main Results:
- The majority of pediatric CCHF cases occurred in June and July, with a predilection for males from rural areas.
- Common symptoms included fever, nausea, malaise, and headache. Leukopenia and thrombocytopenia were frequent initial findings.
- Liver involvement, anemia, and bleeding complications were observed. The overall mortality rate was 4.7%.
Conclusions:
- Early diagnosis and prompt referral to specialized centers are critical for improving outcomes in pediatric CCHF.
- Ecological and environmental changes may contribute to future CCHF epidemics.
- Continued surveillance and research are necessary to manage CCHF in pediatric populations.
Aim:
To analyse the epidemiological and clinical features of children with Crimean-Congo haemorrhagic fever (CCHF) in north-eastern Turkey.
Methods:
A retrospective study of demographic features and physical and laboratory findings in 21 children with CCHF is described. Clinical course, treatment modalities and outcome were analysed.
Results:
Most patients were admitted in June and July 2008; most were from the Gumushane and Kelkit valleys and half of them lived in rural areas. Mean (SD) age was 10.3 (3.9) years and the disease was more common in males (71.4%). Approximately 70% had a history of tick bite. The main symptoms were fever (17, 80.9%), nausea (11, 52.3%), malaise (10, 47.6%) and headache (7, 33.3%). At initial examination, approximately 70% of patients had leukopenia and 65% had thrombocytopenia. Anaemia developed during follow-up in six patients. Liver involvement was seen in 12 patients and one patient had acute tubular necrosis. Six patients had haemophagocytosis. Patients were hospitalised for a median 8 days (range 3-22) and nine patients had bleeding from various sites approximately 3-5 days after hospitalisation. Subcutaneous haematoma (6), especially epistaxis and at venepuncture sites (6) were the most common sites of bleeding. Pulmonary haemorrhage developed in two patients and they required ventilatory support. Overall mortality related to CCHF was 4.7% (one patient).
Conclusion:
Early diagnosis of CCHF and early referral to specialised centres are important for outcome. Exceptional epidemics may be seen in future owing to ecological and environmental changes.
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