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Alterations in the intestinal microbiota and functional bowel symptoms
1Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill School of Medicine, 4107 BioInformatics Building, CB# 7080, 130 Mason Farm Road, Chapel Hill, NC 27599-7080, USA. ringel@med.unc.edu
Gastrointestinal Endoscopy Clinics of North America
|February 24, 2009
Summary
Functional gastrointestinal disorders (FGIDs) are common, and research suggests the gut microbiota may play a role. This review explores the link between intestinal microbiota and FGIDs, discussing their impact on gut function and symptoms.
Area of Science:
- Gastroenterology
- Microbiology
- Human Health
Background:
- Functional gastrointestinal disorders (FGIDs) are prevalent globally.
- The exact causes of FGIDs, including Irritable Bowel Syndrome (IBS), remain unclear.
- Emerging research highlights the potential role of the intestinal microbiota in FGID pathogenesis.
Purpose of the Study:
- To review existing literature on the intestinal microbiota and FGIDs.
- To discuss the relationship between gut microbiota composition and FGIDs.
- To explore how the intestinal microbiota influences intestinal function and symptoms.
Main Methods:
- Literature review of relevant studies.
- Analysis of data linking microbiota to FGIDs.
- Discussion of current scientific understanding.
Main Results:
- The intestinal microbiota is increasingly implicated in FGIDs.
- Specific microbial compositions may correlate with functional bowel symptoms.
- Further research is needed to fully elucidate these connections.
Conclusions:
- The gut microbiota is a significant area of focus for understanding FGIDs.
- Modulating the intestinal microbiota may offer therapeutic potential for FGIDs.
- Continued investigation into microbiota-gut interactions is crucial.
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