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Antitumor properties of Gymnosperma glutinosum leaf extracts
R Gomez-Flores1, L Verástegui-Rodríguez, R Quintanilla-Licea
1Department of Microbiology and Immunology, Biological Sciences College, Autonomous University of Nuevo Leon, N.L., Mexico. rgomez60@hotmail.com
Abstract:
The present study was undertaken to validate the antitumor potential of Gymnosperma glutinosum from regional people's account, using the in vitro and in vivo L5178Y-R lymphoma murine model. Non-polar G. glutinosum crude extracts were tested on L5178Y-R cells. We found significant (p < 0.05) cytotoxic activity (up to 40%) of the hexane extract, which was further fractioned; fraction 1 (F1) was then observed to produce up to 51% apoptosis-mediated L5178Y-R cytotoxicity in vitro at concentrations lower than 0.98 microg/ml, and possess significant in vivo antitumor activity. This study may support further evaluation of active F1 in clinical trials.