Related Experiment Video
Updated: Jun 25, 2026

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
Blood lymphocyte proliferation reaction in autoimmune thyropathies
O I Urazova1, E B Kravets, Yu V Nedosekova
1Siberian State Medical University, Russian Ministry of Health, Tomsk, Russia.
Abstract:
Spontaneous and stimulated reaction of lymphocyte proliferation and blood levels of CD25- and CD120-expressing lymphocytes were studied in patients with autoimmune thyroiditis and diffuse toxic goiter. Activation of CD25- and CD120-presenting function of blood lymphocytes was revealed. The findings indicate that the course of autoimmune thyroiditis and diffuse toxic goiter is associated with increased levels of basal, mitogen- and cytokine-stimulated proliferation of blood lymphocytes, particularly pronounced in thyroiditis in the euthyrosis stage.
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