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Updated: Jun 25, 2026

A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo
Published on: May 16, 2020
Ultrastructural signs of cyclophosphamide-induced damage to cardiomyocytes
E L Lushnikova1, L M Nepomnyashchikh, E A Sviridov
1Institute of Regional Pathology and Pathomorphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia. pathol@soramn.ru
Abstract:
Ultrastructural changes in rat cardiomyocytes were studied after single administration of cyclophosphamide in the therapeutic dose. The major signs of cyclophosphamide-induced damage to cardiomyocytes included moderate lysis of myofibrils, dilation of vesicles in the granular and agranular sarcoplasmic reticulum, and destruction of mitochondria with the formation of myelin-like residual bodies. Ultrastructural changes in cardiomyocyte nuclei primarily manifested in variations of the shape, deep invaginations of the nuclear membrane, and translocation into the subsarcolemmal region.
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