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Updated: Jun 25, 2026
11:15
Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug Combinations
Published on: July 24, 2021
[Polymicrobial infections and new antimicrobial drugs]
Sinisa Sević1, Jovan Vukadinov, Vesna Turkulov
1Klinicki centar Vojvodine, Klinika za infektivne bolesti, Hajduk Veljkova 1-9, 21000 Novi Sad. sinsev@eunet.yu
Medicinski Pregled
|March 3, 2009
Summary
The ongoing battle against microbes has led to antimicrobial resistance and the development of new antimicrobials. However, problematic antimicrobial use persists due to over-the-counter access and surveillance gaps.
Area of Science:
- Microbiology
- Pharmacology
- Infectious Diseases
Context:
- The discovery of antibacterial substances in 1877 marked the beginning of the antimicrobial era.
- The continuous evolutionary pressure between microorganisms and antimicrobials has driven the development of resistance and novel therapeutic agents.
- Antimicrobials are crucial for treating complex infections caused by multidrug-resistant strains.
Purpose:
- To explore the historical context of antimicrobial discovery and the subsequent emergence of resistance.
- To highlight the critical role of novel antimicrobials in managing challenging infections.
- To examine the current challenges in antimicrobial usage and surveillance, particularly in Serbia.
Summary:
- The antimicrobial era, initiated in 1877, is characterized by an ongoing struggle against microbial survival and disease.
- This evolutionary battle has resulted in significant antimicrobial resistance but also spurred the creation of new antimicrobial drugs.
- Novel antimicrobials are vital for treating sophisticated infections caused by highly resistant microorganisms.
Impact:
- Antimicrobial resistance poses a significant global health threat, necessitating careful management and surveillance.
- The availability of novel antimicrobials offers hope for treating infections previously deemed untreatable.
- Addressing issues like over-the-counter antimicrobial access and establishing robust surveillance strategies are crucial for combating antimicrobial resistance.
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