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[Intrahepatic cholestasis in hyperthyroidism].

P Raviolo1, M Rizzetto, M Tabone

  • 1Istituto di Medicina interna, Università, Torino.

Recenti Progressi in Medicina
|June 1, 1991
PubMed
Summary
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Hyperthyroidism can rarely cause severe cholestatic liver disease. This endocrine disorder

Area of Science:

  • Endocrinology
  • Hepatology
  • Internal Medicine

Background:

  • Cholestatic liver disease can present with diverse etiologies.
  • Hyperthyroidism is an endocrine disorder characterized by excessive thyroid hormone production.

Observation:

  • Three cases of cholestatic liver disease temporally associated with hyperthyroidism are presented.
  • Liver damage appeared with thyroid hyperfunction and resolved with its amelioration.
  • Exclusion of congestive heart failure, infections, toxins, and obstruction as causes of liver injury.

Findings:

  • Pathological and biochemical evidence of intrahepatic cholestasis was observed.
  • The endocrine disorder, hyperthyroidism, played a role in the cholestatic syndrome's pathogenesis.
  • Intrahepatic cholestasis can be a rare but severe complication of hyperthyroidism.

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Implications:

  • Hyperthyroidism should be considered in the differential diagnosis of unexplained cholestatic liver disease.
  • Recognition of this association can lead to timely diagnosis and management.
  • Further research into the mechanisms linking thyroid dysfunction and cholestasis is warranted.