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Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

Effects of cardiac resynchronization therapy on heart rate turbulence

Beata Sredniawa1, Radoslaw Lenarczyk, Agata Musialik-Lydka

  • 1First Department of Cardiology, Medical University of Silesia, Silesian Center for Heart Diseases, Zabrze, Poland. bms@pro.onet.pl

Pacing and Clinical Electrophysiology : PACE
|March 3, 2009
PubMed

Insights

Cardiac resynchronization therapy (CRT) improved heart rate turbulence (HRT) in heart failure patients. This suggests CRT may enhance baroreflex sensitivity, offering new insights into heart failure management.

Area of Science:

  • Cardiology
  • Heart Failure Management
  • Autonomic Nervous System Function

Background:

  • Cardiac resynchronization therapy (CRT) is known to improve heart failure (HF) symptoms.
  • The impact of CRT on heart rate turbulence (HRT), a marker of autonomic function, remains largely unexplored.

Purpose of the Study:

  • To investigate the effects of CRT on HRT indices in patients with moderate to severe heart failure.
  • To determine if CRT influences baroreflex sensitivity, as indicated by HRT changes.

Main Methods:

  • 58 HF patients (NYHA class III-IV, LVEF ≤35%) received CRT.
  • HRT indices, including turbulence onset (TO) and turbulence slope (TS), were measured via 24-hour ECG before and after 6 months of CRT.
  • Responders and non-responders to CRT were identified at 6 months.

Main Results:

  • CRT significantly increased turbulence slope (TS) from 2.0 ± 1.7 to 3.9 ± 3.1 (P < 0.05).
  • A significant reduction in abnormal HRT indices was observed post-CRT.
  • TS increased significantly in CRT responders but not in non-responders.

Conclusions:

  • CRT improves HRT indices over 6 months in heart failure patients.
  • CRT may exert beneficial effects on baroreflex sensitivity.
  • HRT changes following CRT could serve as a potential indicator of treatment efficacy.
Abstract

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