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Area of Science:

  • Developmental Pediatrics
  • Clinical Genetics
  • Child Psychology

Background:

  • Global developmental delay (GDD) affects a significant number of young children.
  • Identifying predictive markers for abnormal investigations in GDD is crucial for timely intervention.
  • Parental reporting is a valuable, yet often underutilized, source of clinical information.

Purpose of the Study:

  • To determine if parental symptom reports can predict abnormal laboratory investigations in preschoolers diagnosed with GDD.
  • To identify specific parental observations that correlate with abnormal diagnostic test results.

Main Methods:

  • A cross-sectional descriptive study involving 119 preschoolers (81 boys, 38 girls) with GDD.
  • Parents/guardians completed semistructured interviews, the Child Development Inventory (CDI), Possible Problems Checklist (PPC), and Child Behavior Checklist (CBCL).

Main Results:

  • 40% of children had at least one abnormal investigation (MRI, chromosomal analysis, fragile X testing, array CGH).
  • Younger children with more severe delays, who were more passive and less disobedient, were more likely to have abnormal tests.
  • Increased parental reports of language comprehension and social development predicted abnormal investigations, while increased expressive language and fine motor skills predicted normal results.

Conclusions:

  • Parental symptom reporting is a significant predictor of abnormal laboratory investigations in children with GDD.
  • Quantifiable differences in reported developmental ratios can guide the necessity and focus of further medical investigations.