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07:02
Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)
Published on: September 14, 2010
Kaposi sarcoma: changing trend in Calabar, south eastern Nigeria
M E Asuquo1, A Ogunkeyede, E E Bassey
1Department of Surgery, University of Calabar Teaching Hospital, Calabar, Nigeria. mauefas@yahoo.com
Annals of African Medicine
|March 4, 2009
Summary
Kaposi sarcoma (KS) is the most common malignant skin tumor in Calabar, Nigeria, particularly among HIV-positive individuals. Effective HIV prevention and treatment are crucial for reducing KS prevalence.
Area of Science:
- Oncology
- Dermatology
- Infectious Diseases
Background:
- Kaposi sarcoma (KS) is a significant malignant skin tumor in Africa, with prevalence increasing alongside HIV infection.
- Historically endemic, KS has seen a rise linked to the human immunodeficiency virus (HIV) epidemic.
Purpose of the Study:
- To determine the frequency, clinical presentation, and anatomical distribution of Kaposi sarcoma in Calabar, Nigeria.
- To compare the incidence of Kaposi sarcoma with other malignant skin tumors in the region.
Main Methods:
- A retrospective analysis of patients with histologically diagnosed Kaposi sarcoma from January 2005 to December 2006.
- HIV diagnosis was confirmed using enzyme-linked immunosorbent assay (ELISA).
Main Results:
- Kaposi sarcoma was the most frequent malignant skin tumor (38%), followed by squamous cell carcinoma (34.5%).
- Of 11 patients, 81.8% were HIV-positive, with a mean age of 42.9 years.
- The lower limb was the most common site for KS lesions (50%).
Conclusions:
- Kaposi sarcoma is currently the predominant malignant skin tumor in the study region.
- HIV-related Kaposi sarcoma represents the most common clinical subtype.
- Reducing the incidence of HIV infection is essential for controlling Kaposi sarcoma prevalence.
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