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Related Concept Videos

Imaging Biological Samples with Optical Microscopy01:18

Imaging Biological Samples with Optical Microscopy

Optical microscopy uses optic principles to provide detailed images of samples. Antonie van Leeuwenhoek designed the first compound optical microscope in the 17th century to visualize blood cells, bacteria, and yeast cells. In 1830, Joseph Jackson Lister created an essentially modern light microscope. The 20th century saw the development of microscopes with enhanced magnification and resolution.
In optical microscopy, the specimen to be viewed is placed on a glass slide and clipped on the stage...
Phase Contrast and Differential Interference Contrast Microscopy01:26

Phase Contrast and Differential Interference Contrast Microscopy

Phase-Contrast Microscopes
In-phase-contrast microscopes, interference between light directly passing through a cell and light refracted by cellular components is used to create high-contrast, high-resolution images without staining. It is the oldest and simplest type of microscope that creates an image by altering the wavelengths of light rays passing through the specimen. Altered wavelength paths are created using an annular stop in the condenser. The annular stop produces a hollow cone of...
Confocal Fluorescence Microscopy01:16

Confocal Fluorescence Microscopy

Confocal microscopy is an advanced microscopic technique. The prime advantage of the confocal microscope over other microscopy techniques is its ability to block the out-of-focus light from the illuminated samples using pinholes. It is widely used with fluorescence optics to obtain high-resolution, sharp contrast images. Unlike optical microscopes, confocal microscopes use a focused beam of light laser to scan the entire sample surface at different z-planes. These microscopes are, therefore,...
Computed Tomography01:10

Computed Tomography

Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
Total Internal Reflection Fluorescence Microscopy01:05

Total Internal Reflection Fluorescence Microscopy

Total internal reflection fluorescence microscopy or TIRF is an advanced microscopic technique used to visualize fluorophores in samples close to a solid surface with a higher refractive index, such as a glass coverslip. TIRF only allows fluorophores in proximity to the solid surface to be excited. When light from a medium with a lower refractive index (such as air) hits the glass coverslip at a critical angle, the light undergoes total internal reflection stead of passing through the glass.
Electron Microscope Tomography and Single-particle Reconstruction01:07

Electron Microscope Tomography and Single-particle Reconstruction

Transmission electron microscopy (TEM) can be used to determine the 3D structure of biological samples with the help of techniques such as electron microscope tomography and single-particle reconstruction. While single-particle reconstruction can examine macromolecules and macromolecular complexes in vitro conditions only, tomography permits the study of cell components or small cells in vivo.
Electron Tomography
Electron tomography can be performed either in TEM or STEM (scanning transmission...

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Related Experiment Video

Updated: Jun 25, 2026

Simultaneous Brightfield, Fluorescence, and Optical Coherence Tomographic Imaging of Contracting Cardiac Trabeculae Ex Vivo
12:54

Simultaneous Brightfield, Fluorescence, and Optical Coherence Tomographic Imaging of Contracting Cardiac Trabeculae Ex Vivo

Published on: October 2, 2021

Quantum-optical coherence tomography with classical light.

J Lavoie1, R Kaltenbaek, K J Resch

  • 1Institute for Quantum Computing and Department of Physics & Astronomy, University of Waterloo, Waterloo, Canada, N2L 3G1.

Optics Express
|March 5, 2009
PubMed
Summary
This summary is machine-generated.

Chirped-pulse interferometry (CPI) enhances quantum-optical coherence tomography (Q-OCT) imaging with a 10 million times higher signal. This technique overcomes Q-OCT artifacts and improves axial imaging using classical correlations.

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Last Updated: Jun 25, 2026

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Area of Science:

  • Quantum optics
  • Optical imaging
  • Interferometry

Background:

  • Quantum-optical coherence tomography (Q-OCT) offers advantages for axial imaging over conventional methods.
  • Chirped-pulse interferometry (CPI) has shown potential to replicate Q-OCT's benefits.

Purpose of the Study:

  • To utilize CPI for axial interferogram measurements to profile samples.
  • To leverage Q-OCT benefits like automatic dispersion cancellation with significantly improved signal.
  • To address and solve artifact issues present in Q-OCT.

Main Methods:

  • Employing chirped-pulse interferometry (CPI) for axial interferogram measurements.
  • Profiling a sample using the CPI technique.
  • Comparing the signal strength and artifact profile against standard Q-OCT.

Main Results:

  • Achieved a signal 10 million times higher than conventional Q-OCT.
  • Successfully profiled a sample using CPI, demonstrating Q-OCT benefits.
  • Resolved artifacts typically encountered in Q-OCT.

Conclusions:

  • CPI is a powerful technique for enhancing Q-OCT, offering superior signal and artifact reduction.
  • Classical correlation in optical imaging is highlighted as a key factor in the technique's success.
  • CPI provides a robust alternative for high-performance axial imaging.