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Overview of Cell Death

Overview of Cell Death

Cell death is an essential process where the body gets rid of old or damaged cells. Cell proliferation and death need to be balanced, as an imbalance between the two may lead to cancer or autoimmune diseases.
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the 20th century...

Necrosis

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Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
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Cellular Injury IlI: Cellular Death

Cellular Injury IlI: Cellular Death

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Determination

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Related Experiment Video

Updated: Jun 25, 2026

Neurogenesis Using P19 Embryonal Carcinoma Cells

Neurogenesis Using P19 Embryonal Carcinoma Cells

Published on: April 27, 2019

Embryonal neural tumours and cell death.

John Inge Johnsen¹, Per Kogner, Ami Albihn

¹Department of Woman and Child Health, Karolinska Institutet, Astrid Lindgren Children's Hospital, Childhood Cancer Research Unit, Karolinska University Hospital, Stockholm, Sweden.

Apoptosis : an International Journal on Programmed Cell Death

|March 5, 2009

Summary

Childhood brain tumors like medulloblastoma and neuroblastoma resist chemotherapy due to faulty apoptosis. This review explores their development and identifies new therapeutic targets for these embryonal tumors.

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Assessing Cell Cycle Progression of Neural Stem and Progenitor Cells in the Mouse Developing Brain after Genotoxic Stress

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Published on: May 7, 2014

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Last Updated: Jun 25, 2026

Neurogenesis Using P19 Embryonal Carcinoma Cells

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Published on: April 27, 2019

Assessing Cell Cycle Progression of Neural Stem and Progenitor Cells in the Mouse Developing Brain after Genotoxic Stress

Assessing Cell Cycle Progression of Neural Stem and Progenitor Cells in the Mouse Developing Brain after Genotoxic Stress

Published on: May 7, 2014

Area of Science:

Pediatric Oncology
Neuro-oncology
Cancer Biology

Background:

Medulloblastoma and neuroblastoma are aggressive embryonal tumors affecting the central and peripheral nervous systems in children.
These childhood cancers often exhibit poor prognosis, largely due to resistance to conventional chemotherapy.
Both tumor types share a common characteristic: deficient apoptotic (programmed cell death) pathways, inherited from their progenitor cells.

Purpose of the Study:

To review the specific developmental origins of medulloblastoma and neuroblastoma.
To highlight key biological pathways implicated in the pathogenesis of these embryonal tumors.
To identify potential molecular targets for novel therapeutic strategies against these challenging childhood cancers.

Main Methods:

Literature review focusing on embryonal tumor development.
Analysis of biological pathways involved in medulloblastoma and neuroblastoma.
Identification of potential therapeutic targets based on pathway dysregulation.

Main Results:

Understanding the embryonal origin provides context for tumor biology.
Deficient apoptosis is a critical factor in treatment resistance for both tumor types.
Specific molecular pathways are implicated in tumor initiation and progression.

Conclusions:

Targeting deficient apoptotic machinery and related pathways offers promise for new treatments.
Novel therapeutic approaches are needed to overcome chemotherapy resistance in pediatric embryonal tumors.
Further research into these biological pathways could lead to improved clinical outcomes for children with medulloblastoma and neuroblastoma.