Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Vascular Spasm01:16

Vascular Spasm

The vascular phase, also known as vasospasm, is the initial stage of hemostasis, crucial for preventing excessive bleeding when a blood vessel is injured. After a vessel is cut, nerves in the damaged area trigger pain and other sensory impulses. Simultaneously, the smooth muscles in the vessel wall contract, resulting in a vascular spasm. This contraction reduces the vessel's diameter at the injury site, slowing or stopping blood loss through the vessel wall. Vascular spasms typically last for...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Intracranial Atherosclerotic Disease Distribution Across Circle of Willis Segments: Insights from CREST-H.

AJNR. American journal of neuroradiology·2026
Same author

Ischemic Stroke Incidence and Severity and Poststroke Cognitive Decline and Incident Dementia.

JAMA network open·2026
Same author

Listening to a Consonant Chord Progression during Live Face-to-Face Gaze Enhances Neural Activity in Social Systems.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same author

Association of lipoprotein(a), oxidized phospholipids and apolipoprotein B100 in acute ischemic stroke cohort.

Advances in lipoprotein(a) research·2026
Same author

Association between preeclampsia and reversible cerebral vasoconstriction syndrome: A case-control study.

Pregnancy (Hoboken, N.J.)·2026
Same author

Investigating face processing in online interactions via UK-US hyperscanning using fNIRS.

Imaging neuroscience (Cambridge, Mass.)·2026

Related Experiment Video

Updated: Jun 25, 2026

A Modified Model Preparation for Middle Cerebral Artery Occlusion Reperfusion
04:18

A Modified Model Preparation for Middle Cerebral Artery Occlusion Reperfusion

Published on: May 31, 2024

Reperfusion normalizes motor activation patterns in large-vessel disease.

Mohamad Chmayssani1, Ronald M Lazar, Joy Hirsch

  • 1Department of Neurology, Columbia University Medical Center, New York, NY 10032, USA.

Annals of Neurology
|March 5, 2009
PubMed
Summary
This summary is machine-generated.

Restoring blood flow to the brain normalizes motor activation patterns. This study shows the brain’s dynamic functional reorganization reverses when hypoperfusion is treated, highlighting the importance of hemodynamic stability.

More Related Videos

Optimization of the Longa Middle Cerebral Artery Occlusion Method for Complete Reperfusion
13:18

Optimization of the Longa Middle Cerebral Artery Occlusion Method for Complete Reperfusion

Published on: November 22, 2024

Middle Cerebral Artery Occlusion Allowing Reperfusion via Common Carotid Artery Repair in Mice
06:59

Middle Cerebral Artery Occlusion Allowing Reperfusion via Common Carotid Artery Repair in Mice

Published on: January 23, 2019

Related Experiment Videos

Last Updated: Jun 25, 2026

A Modified Model Preparation for Middle Cerebral Artery Occlusion Reperfusion
04:18

A Modified Model Preparation for Middle Cerebral Artery Occlusion Reperfusion

Published on: May 31, 2024

Optimization of the Longa Middle Cerebral Artery Occlusion Method for Complete Reperfusion
13:18

Optimization of the Longa Middle Cerebral Artery Occlusion Method for Complete Reperfusion

Published on: November 22, 2024

Middle Cerebral Artery Occlusion Allowing Reperfusion via Common Carotid Artery Repair in Mice
06:59

Middle Cerebral Artery Occlusion Allowing Reperfusion via Common Carotid Artery Repair in Mice

Published on: January 23, 2019

Area of Science:

  • Neuroscience
  • Cerebrovascular Medicine
  • Functional Neuroimaging

Background:

  • Hemodynamic impairment can cause atypical motor activation in the contralateral hemisphere.
  • Understanding brain plasticity in response to hypoperfusion is crucial.

Purpose of the Study:

  • To investigate if reversing hypoperfusion normalizes motor activation patterns.
  • To explore the reversibility of brain functional reorganization.

Main Methods:

  • Compared functional MRI motor activation in four patients with stenosis and impaired vasomotor reactivity (VMR) before and after VMR normalization to seven healthy controls.
  • Utilized voxel-wise statistical parametric maps and region of interest analysis during a hand closure task.

Main Results:

  • VMR normalization, achieved through spontaneous resolution or revascularization, was associated with a significant reduction in atypical contralateral motor activation (p < 0.001).
  • Both statistical and region of interest analyses confirmed the normalization of activation patterns.

Conclusions:

  • The brain exhibits dynamic functional reorganization to the opposite hemisphere under stress like hypoperfusion.
  • Restoring normal blood flow reverses these adaptive changes, underscoring the role of ipsilateral function in neurological health.