Related Experiment Video

Updated: Jun 25, 2026

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis
08:44

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis

Published on: September 7, 2022

Recurrent fever and rash

Katherine Cashen1, Deepak Kamat

  • 1Carman and Adams Department of Pediatrics, Children's Hospital of Michigan, Detroit, Michigan, USA.

Clinical Pediatrics
|March 7, 2009
PubMed

Insights

Periodic fever syndromes are rare in children. This case highlights the importance of considering tumor necrosis factor receptor-1 alpha periodic syndrome in children with recurrent fevers and associated symptoms.

Area of Science:

  • Pediatric Rheumatology
  • Immunology

Background:

  • Periodic fever syndromes (PFS) are uncommon in children.
  • A broad differential diagnosis exists for recurrent fevers in pediatric patients.
  • Associated symptoms like rash can aid in differential diagnosis.

Observation:

  • A 4-year-old boy presented with recurrent fever, vomiting, abdominal pain, myalgias, and rash.
  • The patient required emergency department evaluation for these symptoms.
  • Atypical presentations necessitate thorough diagnostic evaluation.

Findings:

  • The case details the hospital course of a child with recurrent fever.
  • The article reviews tumor necrosis factor receptor-1 alpha periodic syndrome.
  • This syndrome is a rare cause of periodic fever in children.

Implications:

  • Early recognition and diagnosis of periodic fever syndromes are crucial.
  • Understanding atypical presentations improves diagnostic accuracy.
  • Proper management of tumor necrosis factor receptor-1 alpha periodic syndrome can prevent complications.

More Related Videos

Recurrent Escherichia coli Urinary Tract Infection Triggered by Gardnerella vaginalis Bladder Exposure in Mice08:53

Recurrent Escherichia coli Urinary Tract Infection Triggered by Gardnerella vaginalis Bladder Exposure in Mice

Published on: December 4, 2020

Related Concept Videos

Patterns of Fever01:26

Patterns of Fever

Before understanding the types and patterns of fever, it is essential to know its phases.
Types of Fever01:25

Types of Fever

Fever can be triggered by several factors, including infections, nervous system disorders, certain cancers, blood diseases like leukemia, embolism, thrombosis, heatstroke, dehydration, surgical trauma, crushing injuries, and allergic reactions.
Here are the different types of fever:
Rocky Mountain Spotted Fever01:26

Rocky Mountain Spotted Fever

Rocky Mountain Spotted Fever (RMSF) is a severe tick-borne illness caused by Rickettsia rickettsii, a Gram-negative, coccobacillary bacterium. This pathogen is an obligate intracellular parasite, requiring a host cell for replication. Transmission occurs through the bite of an infected tick. In the United States, the most important vectors are Dermacentor variabilis (American dog tick) and Dermacentor andersoni (Rocky Mountain wood tick), though other tick species may also serve as vectors.
Increased Body Temperature01:25

Increased Body Temperature

A body temperature above  38°C  (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in response to an infection or illness.
Chickenpox01:20

Chickenpox

Chickenpox is an acute, highly contagious disease caused by the varicella-zoster virus (VZV), a double-stranded DNA virus belonging to the Herpesviridae family. Its transmission occurs primarily through the inhalation of respiratory droplets or direct contact with vesicular fluid from skin lesions. The incubation period typically ranges from 10 to 21 days, during which the virus replicates and disseminates through sequential phases within the host. Although generally self-limiting in children,...
Methods of reducing fever01:22

Methods of reducing fever

The signs and symptoms of fever include hot and dry skin, flushed face, thirst, muscle aches, anorexia, headache, tachycardia, tachypnea, and fatigue. Elevated body temperature is reduced using two methods: pharmacological and nonpharmacological. Proper identification and treatment of the root cause of a fever is of utmost importance.
Pharmacological Methods of Reducing Fever: