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[Effects and side effects of intravenous gamma globulin I: the problem of immune complex formation]

G P Tilz1, U Nydegger

  • 1Medizinischen Universitätsklinik Graz, Inselspitals Bern, Schweiz.

Wiener Medizinische Wochenschrift (1946)
|January 1, 1991
PubMed

This is an original contribution to the side effects of i.v. gamma globulin in patients with immunodeficiency. 73 therapies were carried out, 9 patients suffered from partially life-threatening complications. All side effects were fully reversible and occurred during the transition from antigenaemia to antibody-excess. Immunecomplexes could be quantified and C4 decreased. In view of these results we have modified our protocol giving 5 S prior to 7 S. No further complication was seen in the following 148 therapies. Hence we can conclude, that at least some complications of the i.v. gamma globulin-therapy is due to the formation of immunecomplexes and can be prevented by the application of 5 S prior to 7 S.

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