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The diabetic heart: clinical, experimental and pathological features
1Albert Einstein College of Medicine, Bronx, New York.
Acta Cardiologica
|January 1, 1991
Summary
Diabetic heart disease is worsened by hypertension. Controlling both diabetes mellitus and hypertension may mitigate severe cardiac complications in patients.
Area of Science:
- Cardiology
- Endocrinology
- Pathology
Background:
- Patients with diabetes mellitus face increased cardiovascular disease risk.
- Complications are more severe when diabetes coexists with hypertension.
- Hypertension is a critical factor in severe diabetic heart disease pathogenesis.
Purpose of the Study:
- To investigate the combined impact of diabetes mellitus and hypertension on cardiac health.
- To elucidate the roles of diabetes and hypertension in the development of heart disease.
Main Methods:
- Review of human and experimental animal model evidence.
- Analysis of histopathologic myocardial damage and myocellular dysfunction in hypertensive-diabetic cardiomyopathy.
Main Results:
- Hypertension contributes to myocardial damage, while diabetes causes myocellular dysfunction.
- The combined effect of diabetes and hypertension on the myocardium is devastating.
- Microvascular consequences of both conditions exacerbate heart disease.
Conclusions:
- Strict control of diabetes mellitus and hypertension is crucial.
- Preventing microvascular complications may ameliorate diabetic heart disease progression.