Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Functional Brain Systems: Limbic System01:15

Functional Brain Systems: Limbic System

The limbic system, often called the "emotional brain," is a complex set of structures located deep within the brain. The intricate network of the limbic system supports a wide range of psychological functions, from emotional regulation to memory formation and sensory processing. This functional brain region encompasses specific parts of the diencephalon and the cerebrum, integrating the higher mental functions of the cerebral cortex with the primitive emotional responses of the deep brain...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A human subcortical connectome at 400 μm resolution.

bioRxiv : the preprint server for biology·2026
Same author

Multi-dimensional diffusion MRI at ultra-high gradient strength for mapping axonal architecture and microstructure in the primate brain.

bioRxiv : the preprint server for biology·2026
Same author

Medial prefrontal-thalamic white matter microstructure is associated with harm avoidance in OCD: a discovery and transdiagnostic replication study.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2026
Same author

The modular nature of long-association pathways in the human brain.

bioRxiv : the preprint server for biology·2026
Same author

Millennium Pathways for Tractography: 40 grand challenges to shape the future of tractography.

ArXiv·2025
Same author

Sturge-Weber Syndrome Without Cutaneous Stigmata Versus Encephalocraniocutaneous Lipomatosis Without Craniocutaneous Lipomatosis: A Case Report.

WMJ : official publication of the State Medical Society of Wisconsin·2025

Related Experiment Video

Updated: Jun 25, 2026

Intra-Operative Behavioral Tasks in Awake Humans Undergoing Deep Brain Stimulation Surgery
12:04

Intra-Operative Behavioral Tasks in Awake Humans Undergoing Deep Brain Stimulation Surgery

Published on: January 6, 2011

Cognitive and limbic circuits that are affected by deep brain stimulation.

Suzanne N Haber1, Justin L Brucker

  • 1Department of Pharmacology and Physiology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, New York 14642, USA. suzanne_haber@urmc.rochester.edu

Frontiers in Bioscience (Landmark Edition)
|March 11, 2009
PubMed
Summary

The neural network involving the prefronto-basal ganglia system is central to obsessive-compulsive disorder and depression. Understanding these connections may lead to more precise deep brain stimulation targets for these conditions.

More Related Videos

Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus
09:46

Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus

Published on: March 8, 2015

Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models
14:14

Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models

Published on: August 12, 2018

Related Experiment Videos

Last Updated: Jun 25, 2026

Intra-Operative Behavioral Tasks in Awake Humans Undergoing Deep Brain Stimulation Surgery
12:04

Intra-Operative Behavioral Tasks in Awake Humans Undergoing Deep Brain Stimulation Surgery

Published on: January 6, 2011

Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus
09:46

Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus

Published on: March 8, 2015

Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models
14:14

Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models

Published on: August 12, 2018

Area of Science:

  • Neuroscience
  • Psychiatry
  • Neurosurgery

Background:

  • The pathophysiology of obsessive-compulsive disorder (OCD) and depression involves the prefronto-basal ganglia system.
  • Key regions include the anterior cingulate cortex, orbital prefrontal cortex, ventral striatum, thalamus, amygdala, midbrain dopamine cells, and serotonergic neurons.
  • These areas are implicated in reward learning, decision-making, mood regulation, and addictive behaviors.

Purpose of the Study:

  • To investigate the neural circuitry underlying OCD and depression.
  • To identify potential deep brain stimulation targets within this network.

Main Methods:

  • Review of existing evidence on the neural basis of OCD and depression.
  • Analysis of deep brain stimulation targets in white matter tracts.

Main Results:

  • The prefronto-basal ganglia system, including specific cortical and subcortical regions, is critically involved in OCD and depression.
  • Successful deep brain stimulation targets for OCD and depression are located in white matter tracts connecting these regions.
  • These targets capture crucial ascending and descending connections, particularly those linking the subgenual anterior cingulate and orbital cortex with the basal ganglia, thalamus, and amygdala.

Conclusions:

  • The prefronto-basal ganglia network is a key focus for understanding and treating OCD and depression.
  • Current deep brain stimulation targets leverage white matter tracts within this network.
  • Further detailed knowledge of these connections could enable more refined therapeutic targeting.