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Updated: Jun 25, 2026

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Published on: June 21, 2018
Interleukin-1beta gene (IL-1beta) polymorphisms (SNP -511 and SNP +3953) in thyroid-associated ophthalmopathy (TAO)
Katarzyna Lacka1, Agnieszka Paradowska, Teresa Gasinska
1Department of Endocrinology, University of Medical Science, Poznan, Poland. K_Lacka@wp.pl
Objective:
The aim of this study was to evaluate whether the IL-1beta gene could be a genetic marker of the thyroid-associated ophthalmopathy (TAO) development.
Materials And Methods:
The IL-1beta gene polymorphisms at -511 and +3953 regions in 117 TAO patients of Polish origin (ATA/NOSPECS class III or greater) and in 106 controls were studied.
Results:
We found no significant differences in the frequencies of genotypes and allelic variants for SNP -511 and SNP +3953 between the controls and the studied groups.
Conclusions:
No association between the IL-1beta polymorphisms and the TAO existed, so those polymorphisms are not suitable genetic markers for TAO.
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