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Published on: August 26, 2025
The modified Fontan procedure and prolonged pleural effusions
Christopher E Mascio1, Matthew Wayment, Tarah T Colaizy
1Division of Thoracic and Cardiovascular Surgery, Department of Surgery, University of Louisville, 201 Abraham Flexner Way, Suite 1200, Louisville, KY 40202, USA. cmascio@ucsamd.com
Insights
Prolonged pleural effusions are common after the modified Fontan procedure. Higher preoperative pulmonary artery pressure may predict these effusions, impacting chest tube use and hospital stay.
Area of Science:
- Pediatric Cardiology
- Congenital Heart Surgery
- Thoracic Surgery
Background:
- The modified Fontan procedure is a critical surgery for single-ventricle congenital heart defects.
- Prolonged pleural drainage is a frequent complication, but its predictors remain unclear.
Purpose of the Study:
- To identify perioperative variables associated with prolonged pleural effusions following the modified Fontan procedure.
- To understand risk factors for extended drainage and hospitalization after Fontan surgery.
Main Methods:
- Retrospective analysis of 41 patients undergoing the modified Fontan procedure.
- Comparison of perioperative data between patients with and without prolonged pleural effusions (defined as >14 days).
- Statistical analysis to identify significant risk factors, including preoperative pulmonary artery pressure, Fontan type, and fenestration.
Main Results:
- Ten patients (24%) experienced prolonged pleural effusions.
- Patients with prolonged effusions had significantly higher mean chest tube output, longer chest tube duration, and increased length of hospital stay.
- Elevated preoperative mean pulmonary artery pressure was significantly associated with prolonged effusions (P=0.001).
- Fontan type, fenestration, and conduit size were not identified as risk factors.
Conclusions:
- Prolonged pleural effusions are a significant complication after the modified Fontan procedure.
- Preoperative mean pulmonary artery pressure is a potential predictor of prolonged pleural effusions.
- Further research may focus on managing elevated pulmonary artery pressure to reduce effusions.
Abstract:
The modified Fontan procedure may be complicated by prolonged pleural drainage. Predisposing factors are not fully understood. This study examines perioperative variables associated with prolonged effusions. We examined the Fontan procedure in 41 patients. Mean age was 45 months (range, 9 to 113 months). Mean weight was 14.7 kg (range, 6.9 to 30.4 kg). Diagnoses included tricuspid atresia in 29 per cent, pulmonary atresia in 12 per cent, and double-outlet right ventricle in 12 per cent. Fontan revisions were excluded. The extracardiac Fontan was performed in 22 patients (54%) and the lateral tunnel (LT) in 18 (44%). Fenestration was performed in 56 per cent. Ten patients (24%) had prolonged pleural effusions. Mean chest tube output (24.2 vs 14.1 mL/kg/d, P < 0.01), days with chest tubes (10.2 vs 5.8 days, P < 0.01), and length of stay (20.8 vs 8.13 days, P < 0.01) were significantly greater in those with effusions. Preoperative mean pulmonary artery pressure was higher in patients with prolonged effusions (12.7 vs 9.90 mmHg, P = 0.001). No other factors were identified as risk factors. Prolonged pleural effusions (greater than 14 days) are common after the modified Fontan procedure. A higher preoperative mean pulmonary artery pressure may be predictive of these effusions. Fenestration, type of Fontan reconstruction, and size of extracardiac conduit did not predispose to postoperative effusions.
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