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Updated: Mar 24, 2026

Author Spotlight: Achieving High-Purity In Vitro Differentiation of Th17 Cells Using Cytokine Concentration Modulation
Published on: October 25, 2024
[Contribution of Th-1, Th-2, Th-17 or regulatory T cells to connective tissue diseases]
Motomu Hashimoto1, Shimon Sakaguchi
1Department of Experimental Pathology, Institute for Frontier Medical Science, Kyoto University.
Abstract:
Connective tissue diseases (or systemic autoimmune diseases), such as rheumatoid arthritis or systemic lupus erythematosus, are characterized by B cell hyperactivity and production of various autoantibodies. T cells help B cell activation in the germinal center by enhancing somatic hypermutation and generation of high affinity pathogenic autoantibodies. Previously helper T cells were divided into Th-1 and Th-2 cells. Recently, Th-17 cells and regulatory T cells have been identified as distinct T cell lineages and their roles in inflammation or immune regulation are under intensive investigation. In this review, we discuss the contribution of each T cell subset to autoantibody production and systemic autoimmune diseases.
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