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Updated: Jun 24, 2026

A Periprosthetic Joint Candida albicans Infection Model in Mouse
Published on: February 2, 2024
Prosthetic infection: lessons from treatment of the infected vascular graft
Gabriel Herscu1, Samuel Eric Wilson
1Department of Surgery, University of California, Irvine Medical Center, Orange, CA 92868, USA. gherscu@uci.edu
Abstract:
Surgical prosthetics provide unquestioned benefit to patients in maintenance of life and limb. However, complications associated with prosthetic devices continue to represent a significant source of morbidity and mortality. Even as the surgeon becomes more adept at management of infections, the bacterial characteristics change in favor of increased virulence and greater resistance to antimicrobials. Excision or retention of the prosthesis depends on the time of presentation, the microbial isolates recovered, and the extent of surrounding tissue destruction. Recent work shows improving results with in situ replacement.
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