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Updated: Jun 24, 2026

Temperature-Controlled Assembly and Characterization of a Droplet Interface Bilayer
Published on: April 19, 2021
Partition coefficients of 1-alkanols between water and DDAB vesicle membrane determined by differential conductivity
Hideo Kawamura1, Masahiro Manabe, Masako Myoujou
1Department of Applied Chemistry and Biotechnology, Niihama National College of Technology, Niihama, Ehime, Japan. kawamura@chem.niihama-nct.ac.jp
Abstract:
The partition coefficients of 1-alkanols between water and didodecyldimethylammonium bromide (DDAB) vesicle membrane, and the change of the degree of counter-ion dissociation on DDAB vesicle caused by the solubilization of 1-alkanols were determined from electric conductivity measurements. A good linear relationship was obtained between logarithmic value of the partition coefficient and carbon number of alkyl chain in 1-alkanols. The standard transfer free energy change per methylene group was evaluated from the slope of this straight line. On the other hand, the effect of 1-alkanols on the degree of counter-ion dissociation was independent of carbon number of 1-alkanols. Comparing the results of the present system with those of sodium dodecylsulfate (SDS) micelle/1-alkanol system, it was found that the interior of DDAB vesicle membrane is more hydrophobic than that of SDS micelles. Furthermore, the increase in counter-ion dissociation caused by solubilized 1-alkanols was much lesser for DDAB vesicles than SDS micelles.
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