In-hospital mortality among black patients admitted for hypertension-related disorders in Mbuji Mayi, Congo
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Jean-René M'Buyamba-Kabangu1, Rachel T Biswika, Lutgarde Thijs
1Hypertension Unit, Department of Internal Medicine, University of Kinshasa Hospital, Kinshasa, The Democratic Republic of Congo.
Insights
High in-hospital mortality from hypertension affects sub-Saharan Africa. Improved hypertension screening and treatment are crucial for cardiovascular disease prevention in the region.
Area of Science:
- Cardiology
- Public Health
- Epidemiology
Background:
- Sub-Saharan Africa experiences a high burden of cardiovascular disease (CVD) due to hypertension.
- Hypertension is a significant risk factor for CVD, leading to widespread health challenges in the region.
Purpose of the Study:
- To assess in-hospital mortality rates among patients admitted for hypertension-related diseases in Mbuji Mayi, Congo.
- To identify factors associated with in-hospital mortality in this patient population.
Main Methods:
- A study was conducted in two city hospitals in Mbuji Mayi, Congo.
- In-hospital mortality was assessed in 401 patients admitted for hypertension-related diseases.
- Data on anthropometrics, blood pressure, cardiovascular risk factors, and hypertension awareness/treatment were collected. Stepwise logistic regression was used to model the probability of death.
Main Results:
- The in-hospital mortality rate was 22.2% (89 deaths).
- Factors associated with increased mortality included higher systolic blood pressure, higher body mass index, awareness of hypertension, and untreated hypertension.
- Factors associated with decreased mortality included older age and higher creatinine clearance.
Conclusions:
- In-hospital mortality for hypertension-related disorders in this Congolese city exceeds 20%.
- These findings highlight the urgent need to prioritize hypertension screening, treatment, and CVD prevention in sub-Saharan Africa.
- Elevating hypertension management on the political agenda is essential for public health in the region.
Background:
As a consequence of hypertension, sub-Saharan Africa faces an epidemic of cardiovascular disease.
Methods:
We assessed in-hospital mortality among patients admitted for hypertension-related diseases to two city hospitals in Mbuji Mayi, Congo. On admission, we obtained anthropometric measurements, blood pressure, information on cardiovascular risk factors, and on the awareness and treatment of hypertension. We modeled the probability of death, using stepwise logistic regression.
Results:
Of 401 consecutive patients (mean age, 54.3 years; 129 women), 118 (29.4 %) were unaware of their hypertension. Among 283 aware patients (70.6%), 126 (44.5%) were untreated. Systolic/diastolic blood pressure on admission averaged 178/106 mm Hg. In addition to hypertension, 390 patients (97.3%) had other cardiovascular risk factors, including a creatinine clearance below 60 ml/min/1.73 m(2) in 47 subjects (11.7%). Over 15 days (median) of hospitalization, 89 deaths (22.2%) occurred. The multivariable-adjusted probability of death increased with systolic blood pressure (odds ratio (95% confidence interval) for +10 mm Hg, 1.43 (1.15-1.77); P < 0.01), body mass index (+5 kg/m(2), 2.40 (1.39-4.17); P < 0.01), being aware vs. unaware of hypertension (3.17 (1.52-6.61); P < 0.01), and being untreated (2.33 (1.12-4.76); P < 0.05), but it decreased with age (+10 years, 0.65 (0.46-0.92); P < 0.05) and higher creatinine clearance (+10 ml/min/1.73 m(2), 0.71 (0.61-0.82); P < 0.001).
Conclusions:
The in-hospital mortality among African patients hospitalized for hypertension-related disorders in a Congolese provincial capital city is over 20%. These findings underscore that screening and treatment for hypertension and the prevention of cardiovascular disease should be placed much higher on the political agenda in sub-Saharan Africa.
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