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Related Concept Videos

Mass Spectrometry: Complex Analysis01:21

Mass Spectrometry: Complex Analysis

Mass spectrometry is an important technique for the identification of pure compounds. However, it has some limitations for the analysis of complex mixtures, often due to excessive fragmentation making the spectrum too complicated to decipher. Mass spectrometry can be combined with suitable separation methods in sequence, forming hyphenated methods, which are useful in the analysis of complex mixtures.
GC–MS is a powerful hyphenated method commonly used in forensics and environmental...

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Related Experiment Video

Updated: Jun 24, 2026

Workflow Based on the Combination of Isotopic Tracer Experiments to Investigate Microbial Metabolism of Multiple Nutrient Sources
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Published on: January 22, 2018

High-throughput trace melamine analysis in complex mixtures.

Guangming Huang1, Zheng Ouyang, R Graham Cooks

  • 1Department of Chemistry and Center for Analytical Instrumentation Development, 560 Oval Drive, Purdue University, West Lafayette, IN 47907, USA.

Chemical Communications (Cambridge, England)
|March 14, 2009
PubMed
Summary
This summary is machine-generated.

A novel ambient ionization method using a low-temperature plasma probe and tandem mass spectrometry can detect melamine in milk products. This technique achieves low ppb detection limits quickly, ensuring food safety.

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Published on: April 23, 2019

Area of Science:

  • Analytical Chemistry
  • Food Science
  • Environmental Science

Background:

  • Melamine contamination in food products poses a significant public health risk.
  • Accurate and rapid detection methods are crucial for ensuring food safety and regulatory compliance.

Purpose of the Study:

  • To develop and validate a rapid analytical method for melamine detection in milk-based products.
  • To assess the performance of ambient ionization with a low-temperature plasma probe coupled to tandem mass spectrometry for melamine quantitation.

Main Methods:

  • Ambient ionization utilizing a low-temperature plasma (LTP) probe.
  • Tandem mass spectrometry (MS/MS) for selective detection and quantitation.
  • Analysis of various milk products including milk powder and whole milk.

Main Results:

  • Successful detection and quantitation of melamine in diverse milk matrices.
  • Achieved low parts-per-billion (ppb) detection limits for melamine.
  • Demonstrated rapid analysis times, with results obtained in tens of seconds.

Conclusions:

  • The combined LTP probe and MS/MS technique offers a highly sensitive and rapid approach for melamine analysis.
  • This method is suitable for routine quality control and safety monitoring of milk products.
  • The speed and sensitivity of this technique contribute to enhanced food safety protocols.