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Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...

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Related Experiment Video

Updated: Jun 24, 2026

Extracellular Vesicle Tissue Factor Activity Assay
03:53

Extracellular Vesicle Tissue Factor Activity Assay

Published on: December 29, 2023

Tissue factor in tumour progression.

Janusz Rak1, Chloe Milsom, Nathalie Magnus

  • 1Montreal Children's Hospital Research Institute, 4060 Ste Catherine West, Montreal, QC, H3Z 3Z2, Canada.

Best Practice & Research. Clinical Haematology
|March 17, 2009
PubMed
Summary

Tissue factor (TF) is a central trigger in blood coagulation and plays a key role in cancer. Understanding TF's role in tumor progression and its potential as a therapeutic target is crucial for advancing cancer treatment.

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Extracellular Vesicle Tissue Factor Activity Assay
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Area of Science:

  • Oncology
  • Hematology
  • Molecular Biology

Background:

  • The link between coagulation system activation and cancer is well-established.
  • Tissue Factor (TF) is deregulated by cancer cells, stroma, and inflammatory cells.
  • TF is a central trigger of coagulation and a cell-associated signaling receptor.

Purpose of the Study:

  • To explore the multifaceted role of TF in cancer.
  • To discuss TF's impact on tumor growth, metastasis, and angiogenesis.
  • To address the potential of TF as a therapeutic target and biomarker in cancer.

Main Methods:

  • Review of preclinical studies on TF regulation and function in cancer.
  • Analysis of TF's role in gene expression, tumor microenvironment, and stem cell niche formation.
  • Discussion of TF-containing microvesicles and their role in cancer progression.

Main Results:

  • TF influences oncogenic transformation, tumor growth, metastasis, and angiogenesis.
  • TF-containing microvesicles contribute to intercellular TF activity transfer and coagulopathy.
  • Differential roles of cell-autonomous versus global TF effects are being investigated.

Conclusions:

  • TF is a critical factor in cancer biology with implications for tumor progression.
  • Further research is needed to determine TF's therapeutic potential and biomarker utility.
  • Clinical questions regarding TF's safe and beneficial application in cancer treatment require exploration.