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Updated: Jun 24, 2026

Modeling Paracrine Noncanonical Wnt Signaling In Vitro
Published on: December 10, 2021
Noncanonical Wnt/PCP signaling during vertebrate gastrulation
1Department of Cell and Developmental Biology, University College London, London, United Kingdom. m.tada@ucl.ac.uk
Abstract:
The branch of the Wnt pathway, related to planar cell polarity signaling in Drosophila, is fundamental not only to the establishment of tissue polarity but also to a variety of morphogenetic processes in vertebrates. The genetic pathway has been noted for its similarity as well as divergence of between vertebrates and Drosophila. This review focuses on issues related to the complexity of the output of the planar cell polarity pathway during gastrulation in zebrafish and Xenopus and, to a lesser extent, during gastrulation/neurulation in mice.
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