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Updated: Jun 24, 2026
12:03
In Vivo Model for Testing Effect of Hypoxia on Tumor Metastasis
Published on: December 9, 2016
Ewing's sarcoma / primitive neuroectodermal tumor of the kidney
Y Funahashi1, R Hattori, T Yamamoto
1Department of Urology, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya, Japan. funa418@yahoo.co.jp
Aktuelle Urologie
|March 19, 2009
Summary
A rare kidney tumor, Ewing's sarcoma, was diagnosed in a 42-year-old female. Successful treatment involved surgery and chemotherapy, with no signs of recurrence after 19 months.
Area of Science:
- Oncology
- Pathology
- Genetics
Background:
- Ewing sarcoma/primitive neuroectodermal tumor (ES/PNET) is a rare and aggressive malignancy.
- Primary renal ES/PNET is exceptionally uncommon, particularly in adults.
- Early and accurate diagnosis is crucial for effective treatment and patient outcomes.
Observation:
- A 42-year-old female presented with right back pain and a large (72 mm) space-occupying lesion in the right kidney.
- Imaging revealed a significant renal mass without evidence of metastasis.
- Surgical resection was performed, followed by histopathological and genetic analyses.
Findings:
- Histopathology confirmed a high-grade primitive small round tumor.
- Immunohistochemistry showed strong positivity for CD99 and vimentin.
- Fluorescence in situ hybridization (FISH) detected EWSR1 gene rearrangement, confirming the diagnosis of Ewing sarcoma/primitive neuroectodermal tumor of the kidney.
Implications:
- This case highlights the importance of considering rare diagnoses like renal Ewing sarcoma in adult patients with kidney masses.
- The successful outcome emphasizes the efficacy of a multimodal treatment approach, including surgery and chemotherapy.
- Further research into the specific characteristics and optimal management of primary renal ES/PNET in adults is warranted.
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