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Related Experiment Video

Updated: Jun 24, 2026

A Rodent Model of The Ross Operation: Syngeneic Pulmonary Artery Graft Implantation in A Systemic Position
11:20

A Rodent Model of The Ross Operation: Syngeneic Pulmonary Artery Graft Implantation in A Systemic Position

Published on: April 1, 2022

Thirteen years' experience with the Ross Operation.

Francisco D A da Costa1, Lúcia R Santos, Claudinei Collatusso

  • 1Department of Cardiovascular Surgery of Santa Casa de Curitiba, PUCPR, Curitiba, Paraná, Brazil. fcosta13@mac.com

The Journal of Heart Valve Disease
|March 24, 2009
PubMed
Summary
This summary is machine-generated.

The Ross operation shows excellent long-term survival and low reoperation rates up to 13 years. Pulmonary autograft dilatation is a risk factor, while SDS-decellularized allografts offer promising RVOT reconstruction.

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Area of Science:

  • Cardiovascular Surgery
  • Thoracic Surgery
  • Cardiac Transplantation

Background:

  • The Ross operation involves pulmonary autograft (PA) and right ventricular outflow tract (RVOT) allograft.
  • Long-term functional outcomes and risk factors for these components require evaluation.

Purpose of the Study:

  • To assess 13-year outcomes of the Ross operation.
  • Identify risk factors influencing late PA and RVOT allograft performance.

Main Methods:

  • Retrospective analysis of 272 patients undergoing the Ross operation (May 1995-March 2006).
  • Evaluation of PA root replacement and various RVOT allograft reconstructions (conventional, pericardial extension, deoxycholic acid, SDS decellularized).
  • Mean follow-up of 67 months (1,525 patient-years).

Main Results:

  • Hospital mortality 2.9%, 12-year late survival 93%.
  • 12-year freedom from reoperation for PA and allograft was 97% and 95%, respectively.
  • PA dilatation risk factors: degenerative disease, large aortic annulus. SDS-decellularized RVOT allografts showed lower gradients.

Conclusions:

  • The Ross operation demonstrates excellent long-term survival and low reoperation rates up to 13 years.
  • Late PA dilatation and valvar insufficiency may necessitate future reoperations.
  • SDS-decellularized allografts represent a viable option for RVOT reconstruction.