Related Experiment Video
Updated: Jun 24, 2026

Visualization and Analysis of Pharyngeal Arch Arteries using Whole-mount Immunohistochemistry and 3D Reconstruction
Published on: March 31, 2020
An unusual presentation of a fourth pharyngeal arch (branchial cleft) sinus
Lucas Neff1, Daniel Kirse, Thomas Pranikoff
1Department of Pediatric Surgery, Wake Forest University Baptist Medical Center, NC, USA.
Abstract:
Fourth pharyngeal arch (branchial cleft) sinuses and fistulas are a rare cause of recurrent neck abscesses presenting in the first 2 decades of life. Because they are uncommon, the diagnosis and subsequent treatment can be delayed, even with proper radiographic imaging and clinical evaluation. This case illustrates a life-threatening presentation of a ruptured fourth branchial cleft sinus with extravasation into the mediastinum, chest, and abdomen.
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