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Updated: Jun 24, 2026

Controlled Cortical Impact Model for Traumatic Brain Injury
Published on: August 5, 2014
Plasma oxidation-reduction potential and protein oxidation in traumatic brain injury
Leonard T Rael1, Raphael Bar-Or, Charles W Mains
1Trauma Research Laboratory, Swedish Medical Center, Englewood, CO 80113, USA.
Abstract:
The amount of oxidative stress in patients with an isolated traumatic brain injury (ITBI) can be estimated by measuring several biochemical parameters, such as total antioxidants, lipid peroxidation, protein oxidation, and others. Unfortunately, measuring these parameters is time-consuming, impractical in a clinical setting, and may miss important factors contributing to the overall redox balance. Here we suggest that the overall oxidative status in ITBI patients can be assessed by measuring plasma oxidation-reduction potential (ORP). Daily whole blood samples were obtained from severe ITBI patients (abbreviated injury score [AIS] >or=3, n = 32), and demographically similar non-head injury traumatized patients (n = 26) until discharge. Whole blood was also collected from patients with minor to moderate ITBI (AIS
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