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Related Experiment Video

Updated: Jun 24, 2026

The Microfluidic Probe: Operation and Use for Localized Surface Processing
08:07

The Microfluidic Probe: Operation and Use for Localized Surface Processing

Published on: June 4, 2009

A microfluidic high-resolution NMR flow probe.

Jacob Bart1, Ard J Kolkman, Anna Jo Oosthoek-de Vries

  • 1Mesa+ Institute for Nanotechnology, University of Twente, Drienerlolaan 5, 7522 NB Enschede, The Netherlands.

Journal of the American Chemical Society
|March 27, 2009
PubMed
Summary
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A novel microfluidic nuclear magnetic resonance (NMR) flow probe offers high-resolution reaction monitoring. This tool shows promise for microreactor analysis and metabolomics studies, including cerebrospinal fluid analysis.

Area of Science:

  • Analytical Chemistry
  • Spectroscopy
  • Microfluidics

Background:

  • In situ reaction monitoring is crucial for optimizing microreactor processes.
  • High-resolution Nuclear Magnetic Resonance (NMR) spectroscopy is a powerful analytical technique.
  • Developing specialized NMR probes is essential for advanced analytical applications.

Purpose of the Study:

  • To demonstrate a microfluidic high-resolution NMR flow probe.
  • To showcase its utility for in situ monitoring of reactions in microreactors.
  • To evaluate its potential for metabolomics studies.

Main Methods:

  • Fabrication of a novel stripline detector chip for the NMR probe.
  • Integration of the detector into a microfluidic system.

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Last Updated: Jun 24, 2026

The Microfluidic Probe: Operation and Use for Localized Surface Processing
08:07

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Published on: June 4, 2009

Rapid Subtractive Patterning of Live Cell Layers with a Microfluidic Probe
12:19

Rapid Subtractive Patterning of Live Cell Layers with a Microfluidic Probe

Published on: September 15, 2016

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  • Application of the probe to monitor the acetylation of benzyl alcohol.
  • Analysis of human cerebrospinal fluid using the developed probe.

    • Main Results:

    • The microfluidic NMR flow probe achieved uncompromised sub-Hertz resolution.
    • Successful in situ monitoring of a model reaction (acetylation) was demonstrated.
    • The probe enabled analysis of a small volume (600 nL) of human cerebrospinal fluid.

    Conclusions:

    • The developed microfluidic NMR flow probe is a valuable tool for real-time reaction monitoring.
    • Its high resolution and sensitivity make it suitable for microreactor applications.
    • The probe holds significant potential for future metabolomics research and clinical diagnostics.