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Related Concept Videos

Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
Teratogenicity01:07

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
Fetal Circulation01:14

Fetal Circulation

Fetal circulation is a unique system that facilitates the exchange of gases, nutrients, and waste products between the developing fetus and the mother. This intricate process takes place through a special organ called the placenta.
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...
Development of Blood Vessels01:07

Development of Blood Vessels

The development of the vascular system in a fetus is a complex and intricate process that begins as early as 15 to 16 days post-conception. This process starts outside the embryo, specifically in the mesoderm of the yolk sac, chorion, and connecting stalk. Approximately two days later, the formation of blood vessels occurs within the embryo itself.
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...
Nondisjunction01:21

Nondisjunction

Nondisjunction is the failure of homologous chromosomes or sister chromatids to separate correctly and move to the opposite poles of the cells. This produces daughter cells with abnormal chromosome numbers.  Nondisjunction is common during anaphase I or anaphase II of meiosis.  Mutations in synaptonemal complex proteins that attach homologous chromosomes increase the chances of nondisjunction in anaphase I of meiosis I. In contrast, mutations in topoisomerases and condensins that hold sister...

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Mouse Model of Surgical Uterine Injury and Subsequent Pregnancy Outcomes
04:08

Mouse Model of Surgical Uterine Injury and Subsequent Pregnancy Outcomes

Published on: June 27, 2025

Abnormal placentation.

Samuel T Bauer1, Clarissa Bonanno

  • 1Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Columbia University Medical Center, New York, NY 10032, USA. stb2119@columbia.edu

Seminars in Perinatology
|March 28, 2009
PubMed
Summary
This summary is machine-generated.

Abnormal placentation, or placenta accreta, is a serious pregnancy complication. Early diagnosis via imaging is crucial for planning delivery and managing hemorrhage, with surgical intervention remaining the standard care.

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Last Updated: Jun 24, 2026

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Guide Wire Assisted Catheterization and Colored Dye Injection for Vascular Mapping of Monochorionic Twin Placentas
09:04

Guide Wire Assisted Catheterization and Colored Dye Injection for Vascular Mapping of Monochorionic Twin Placentas

Published on: September 5, 2011

Area of Science:

  • Obstetrics and Gynecology
  • Maternal-Fetal Medicine

Background:

  • Abnormal placentation, specifically placenta accreta, presents significant diagnostic and management challenges in pregnancy.
  • It is a primary cause of postpartum hemorrhage, characterized by placental villi attaching directly to the myometrium.
  • Risk factors include prior uterine surgeries like cesarean sections and dilatation and curettage.

Purpose of the Study:

  • To highlight the diagnostic and treatment challenges of abnormal placentation.
  • To emphasize the importance of prenatal diagnosis for effective management.
  • To review current management strategies for placenta accreta.

Main Methods:

  • Diagnosis typically involves gray-scale ultrasound.
  • Magnetic resonance imaging (MRI) is used for confirmation and to assess the extent of placental invasion.
  • Review of management strategies, including surgical and conservative approaches.

Main Results:

  • Prenatal diagnosis is critical for preoperative planning, significantly reducing blood loss and morbidity.
  • Aggressive hemorrhage management includes uterotonics, fluid resuscitation, blood products, planned hysterectomy, and hemostatic agents.
  • Conservative options like uterine preservation, methotrexate, or pelvic artery embolization may be considered for focal cases.

Conclusions:

  • Placenta accreta requires careful diagnosis and management during pregnancy.
  • Multidisciplinary planning is essential for optimizing patient outcomes.
  • Surgical management is the current standard of care, though conservative measures have a role in select cases.