Related Experiment Video
Updated: Jun 24, 2026

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
Genetics of type 1 diabetes and autoimmune thyroid disease
Simon H S Pearce1, Tony R Merriman
1Institute of Human Genetics, University of Newcastle, International Centre for Life, Newcastle upon Tyne, UK. s.h.s.pearce@ncl.ac.uk
Abstract:
The search for the susceptibility alleles for the complex genetic conditions of type 1 diabetes and autoimmune thyroid diseases has gained momentum in recent years. Studies have revealed several novel disease susceptibility alleles of relevance to both conditions, which brings the total number of genetic variants contributing to type 1 diabetes to ten. Additional genetic loci remain to be discovered, particularly in the autoimmune thyroid diseases. In the future, the density and coverage of single nucleotide polymorphisms available for high throughput genotyping will improve, and detailed analysis of the role of copy number variants in these diseases will shed new light on the pathogenesis of these common endocrinopathies.
Related Concept Videos
Type I Diabetes I: Introduction
Type I Diabetes II: Pathophysiology
Autoimmune Disorders
Concept and Mechanism of Autoimmune Diseases
The immune system...
Type II Diabetes I: Introduction
Graves' Disease I: Introduction
Diabetes Mellitus: Overview and Type I Subtype
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
