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Ewing's sarcoma t(11;22) in a case of acute nonlymphocytic leukemia
J M Hawkins1, J M Craig, L M Secker-Walker
1Cytogenetics, Royal Free Hospital Medical School, London, UK.
Abstract:
Chromosome analysis of bone marrow cells from a patient with acute nonlymphocytic leukemia M2 revealed the translocation t(11;22)(q24;q12) usually associated with Ewing's sarcoma. Molecular investigations ruled out the possibility that this was a variant Philadelphia translocation with breakpoints in the major breakpoint cluster region. Although cytogenetic analysis was not available at diagnosis, this abnormality was found both pre- and postallogeneic bone marrow transplant.
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