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Related Experiment Videos

Growth hormone deficiency in Sri Lanka: a preliminary study.

T de Mel1, N Warnasooriya, C Fonseka

  • 1Faculty of Medicine, University of Colombo.

The Ceylon Medical Journal
|September 1, 1991
PubMed
Summary

Growth hormone deficiency, a cause of short stature, was identified in Sri Lankan children. This study confirms its presence and potential for treatment in the region.

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Area of Science:

  • Pediatrics
  • Endocrinology
  • Human Growth and Development

Background:

  • Growth hormone deficiency (GHD) is a significant cause of severe short stature in children.
  • Previous documentation of GHD is lacking in Sri Lanka, necessitating local epidemiological data.

Purpose of the Study:

  • To screen a Sri Lankan pediatric population for short stature.
  • To investigate the prevalence and aetiology of short stature, specifically identifying cases of GHD.
  • To identify children who may benefit from growth hormone therapy.

Main Methods:

  • Community screening of 16,001 children aged 5-6 years for short stature using growth charts.
  • Diagnostic investigation of 172 identified short children for aetiology.
  • Confirmation of GHD using the insulin-induced hypoglycaemia test.
  • Identification of potential candidates for growth hormone therapy via an exercise screening test.

Main Results:

  • Growth hormone deficiency (GHD) was confirmed in 12 out of 172 investigated children.
  • An additional 27 children were identified as potentially benefiting from growth hormone therapy.
  • This study represents the first documentation of GHD in Sri Lanka.

Conclusions:

  • Growth hormone deficiency is present in the Sri Lankan pediatric population.
  • Screening and diagnostic methods can effectively identify children with GHD.
  • Findings support the need for further investigation and potential therapeutic interventions for GHD in Sri Lanka.

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